Research from Aarhus University in Denmark is providing new details about the structure of a DNA repair complex, information which could improve chemotherapy treatment of cancer. The new paper, published in The Journal of Biological Chemistry, cites Kerafast’s LOBSTR E. coli Expression Strain, developed by Dr. Thomas U. Schwartz at the Massachusetts Institute of Technology
Ninety percent of cancer deaths are related to metastasis, making research to understand its causes and identify potential ways to prevent it very important. In a new Nature Communications study, scientists at the Georgia Cancer Center at Augusta University report that cancer can hijack a certain type of immature immune cell to help it spread.
Stem cells are heavily studied and used as both therapies and disease models. In a recent paper, published in The American Journal of Human Genetics, researchers demonstrated the use of stem cells to study a neurological disease that is the result of several different types of mutations. Pelizaeus-Merzbacher Disease Pelizaeus-Merzbacher Disease (PMD) is a rare
We recently wrote about a Nature study in which scientists identified a human monoclonal antibody able to protect pregnant mice and their developing fetuses from Zika virus infection. The research was led by Dr. James E. Crowe of Vanderbilt University, whose CD40L Expressing Feeder Cell Line, used to generate B cell cultures yielding human monoclonal
Organ transplantation and donation are critical in saving the lives of thousands of people annually. Currently, more than 100,000 people are on an organ donation list waiting for a lifesaving transplant. Despite advances in medicine and awareness of organ donation, there continues to be a shortage of available organs and nearly 22 people a day
Antibodies are Y-shaped proteins produced naturally by the body’s immune system when it detects foreign substances. These proteins are commonly used in research to identify, locate and visualize intracellular and extracellular proteins. Antibodies are also being used for clinical applications, in particular as cancer therapeutics and in vaccine development. Here you’ll find a quick overview
Research from the University of Würzburg is providing new insights into ubiquitin regulation. In a recent study, published in the journal eLife, researchers determined the atomic structure of a ubiquitin ligase implicated in tumor formation, revealing a dimerization mechanism that may be exploited for developing new cancer therapies. The paper cited Kerafast’s LOBSTR E. coli
The gastrointestinal (GI) tract is innervated by the enteric nervous system (ENS) located within the GI tract, as well as through connections to the central nervous system (CNS). The ENS and CNS act in concert to control the homeostatic functions of the GI tract, such as digestion, secretion and motility. The constant, bi-directional communication between
Treatment of severe burns is a critical care issue, especially in developing countries. In the United States, donated human or pig skin is generally used to graft on the injured patient. However, some countries do not have access to the biobanks and animal models necessary for treatment of burn victims. In Brazil, doctors are testing
An international team of researchers, led by Dr. Johanna Ivaska of the Turku Centre for Biotechnology, has found that breast cancer cell metastasis can be prevented by the SHANK protein. Previously, SHANK had only been studied in the central nervous system; it’s mainly known for its link to autism. The new study was published in