Using Nanobodies to Improve CAR T-Cell Therapy

Researchers at Boston Children’s Hospital and MIT have recently been able to show that mini-antibodies called nanobodies – previously discovered more than 20 years ago – may be able to resolve an issue in the cancer field: making chimeric antigen receptor (CAR) T-cell therapies functional in solid tumors. Their research was published in the journal 

Continue Reading…

A Future Focus for Parkinson’s Treatment

In a study published by the Journal of Biological Chemistry, scientists at UPenn School of Veterinary Medicine discovered that the enzyme cytochrome P450 2D6 (CYP2D6) plays a role in triggering Parkinson’s disease and represents a new focus for Parkinson’s treatment. Chemically induced Parkinson’s A few decades ago, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was found to induce the onset 

Continue Reading…

A New Target for Anti-Inflammation Therapeutics

Researchers from Washington State University recently discovered a critical step in the body’s inflammatory response that may aid in the development of anti-inflammatory treatments. Their findings, which were published in the journal Nature Communications, cited an integrin beta 3 antibody developed by researchers at the Blood Center of Wisconsin and now available via the Kerafast 

Continue Reading…

Researchers discover new colon cancer therapeutic target

According to the U.S. Centers for Disease Control and Prevention, colon cancer is the third most common cancer and second leading cause of cancer-related death in the country. Now, food science researchers from the University of Massachusetts Amherst have published a new study in Cancer Research that shows how a set of enzymes can potentially 

Continue Reading…

New paper uncovers the structure of CB2, the second human cannabinoid receptor

Findings from an international group of researchers might help in the development of drugs against inflammatory and neurodegenerative diseases. Their paper, published in Cell, describes the crystal structure of the human cannabinoid receptor CB2. Exploring the Endocannabinoid System CB1 and CB2, two cannabinoid receptors, belong to the endocannabinoid system. CB1 receptors are commonly found in 

Continue Reading…

Combating T cell exhaustion in CAR T cancer therapy

Scientists from the La Jolla Institute of Immunology (LJI) have discovered a way to lessen the effects of T cell exhaustion and make CAR T cell therapies more effective, publishing their results in Nature. We were pleased to see our MC-38 cell line, derived from murine colon adenocarcinoma cells, utilized in the research. The MC-38 

Continue Reading…

An HIV drug may reduce the impact of age-related disorders

Research led by scientists at Brown University now shows that an HIV drug may be able to significantly reduce age-related inflammation and other signs of aging in mice. The collaborative findings — which also included work by researchers from New York University, the University of Rochester, Université de Montréal, the University of Virginia School of 

Continue Reading…

Lysosomes receive calcium through close association with the ER and IP3 receptors

Free calcium in the cytosol is critical for regulating cellular processes in response to intracellular and extracellular stimuli. Calcium signaling involves the opening of calcium channels within the plasma membrane or membranes of intracellular organelles, most notably the endoplasmic reticulum (ER). Extracellular stimuli lead to the release of calcium from the ER in response to 

Continue Reading…