Spicy burn of chili peppers burns fat

Researchers from University of Wyoming have developed Metabocin, an anti-obesity drug derived from capsaicin, the part of a chili pepper that is responsible for its spicy burn. The capsaicin targets TRPV1 receptors to burn the energy in white fat cells rather than store it, and Metabocin has proven to effectively cause long-term weight loss in 

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Exploring alternative treatments for Clostridium difficile infection

Antibiotics have been effectively utilized for decades in the treatment against infectious agents. However, antibiotic use has been known to have detrimental effects, including the development of antibiotic-resistant bacteria and alterations to the microbiota. The microbiota is a community of bacteria that colonize the body and can influence metabolism, physiology, nutrition and immune function. An 

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Do aging lymphatic vessels lead to Alzheimer’s disease?

Until a discovery in 2015, it was believed that the lymphatic vessels surrounding the brain did not exist. Since then, researchers from the University of Virginia have made a connection between the aging vessels and the onset of Alzheimer’s disease. The researchers’ findings were published in the journal Nature. Lymphatic Vessels and the Brain In 

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Is cancer just bad luck?

By Dipanjan Basu, PhD The brief answer to this question is “We don’t know”. But the bigger question here is why should we bother to know? Cancer has been around for a very long time and humanity has come a long way investigating the characteristics and treatments for various kinds of cancer. In fact, in 

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A less invasive way to treat diabetes

Despite the improvements made to weight loss surgeries that reverse diabetes and obesity, numerous patients continue to opt against it, finding it too invasive. This prompted Dr. Ali Tavakkoli of Brigham and Women’s Hospital to find a less invasive way to deliver the same benefits. The goal is to produce a pill that delivers a 

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New insight into DNA repair regulation

A new study has identified an enzyme that regulates DNA repair through deubiquitylation of a key protein. The research, led by University of Sheffield scientists, has implications for better understanding chemotherapy-resistant cancers as well as neurological disorders. The paper, published in Cell Reports, cites Kerafast’s MultiDsk Ubiquitin Binding Protein Reagent, which allows for the capture 

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Promising discovery for T-cell leukemia

In 10% of pediatric T-cell leukemia patients, the BCL-2 protein is overproduced due to a defect in the ribosomes, where proteins for cells are synthesized. A BCL-2 inhibiting drug is currently being used to treat chronic lymphocytic leukemia, but researchers at KU Leuven in Belgium are conducting studies to apply the drug to T-cell leukemia 

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Using stem cells to treat heart failure

The number one cause of death in the world is heart failure, according to the World Health Organization. Causing 80% of the 17.7 million global cardiovascular disease deaths annually, heart failure caused by heart attack or stroke is a huge public health concern. A new study by researchers at the University of Washington has given 

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Rock, Paper, Scissors: P53, the Stock Market, and CRISPR

By Netanya Y. Spencer, MD, PhD On June 11, 2018, Nature Medicine published two papers side-by-side. In one study, Haapaniemi and colleagues studied immortalized human retinal pigment epithelial cells; in the other study, Ihry and colleagues studied human pluripotent stem cells. Both papers presented one major discovery, which plunged a number of stock prices way 

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