Researchers discover new colon cancer therapeutic target

According to the U.S. Centers for Disease Control and Prevention, colon cancer is the third most common cancer and second leading cause of cancer-related death in the country. Now, food science researchers from the University of Massachusetts Amherst have published a new study in Cancer Research that shows how a set of enzymes can potentially 

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New paper uncovers the structure of CB2, the second human cannabinoid receptor

Findings from an international group of researchers might help in the development of drugs against inflammatory and neurodegenerative diseases. Their paper, published in Cell, describes the crystal structure of the human cannabinoid receptor CB2. Exploring the Endocannabinoid System CB1 and CB2, two cannabinoid receptors, belong to the endocannabinoid system. CB1 receptors are commonly found in 

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Combating T cell exhaustion in CAR T cancer therapy

Scientists from the La Jolla Institute of Immunology (LJI) have discovered a way to lessen the effects of T cell exhaustion and make CAR T cell therapies more effective, publishing their results in Nature. We were pleased to see our MC-38 cell line, derived from murine colon adenocarcinoma cells, utilized in the research. The MC-38 

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An HIV drug may reduce the impact of age-related disorders

Research led by scientists at Brown University now shows that an HIV drug may be able to significantly reduce age-related inflammation and other signs of aging in mice. The collaborative findings — which also included work by researchers from New York University, the University of Rochester, Université de Montréal, the University of Virginia School of 

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Lysosomes receive calcium through close association with the ER and IP3 receptors

Free calcium in the cytosol is critical for regulating cellular processes in response to intracellular and extracellular stimuli. Calcium signaling involves the opening of calcium channels within the plasma membrane or membranes of intracellular organelles, most notably the endoplasmic reticulum (ER). Extracellular stimuli lead to the release of calcium from the ER in response to 

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10 unique reagents that helped advance research in 2018

At Kerafast, it’s become an annual tradition at the start of each year to look back at how the reagents in our catalog have helped contribute to scientific progress. Our company mission is to facilitate access to the unique reagents developed by academic laboratories. Together with our providing investigators, we get lab-made reagents out of 

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