A less invasive way to treat diabetes

Despite the improvements made to weight loss surgeries that reverse diabetes and obesity, numerous patients continue to opt against it, finding it too invasive. This prompted Dr. Ali Tavakkoli of Brigham and Women’s Hospital to find a less invasive way to deliver the same benefits. The goal is to produce a pill that delivers a 

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New insight into DNA repair regulation

A new study has identified an enzyme that regulates DNA repair through deubiquitylation of a key protein. The research, led by University of Sheffield scientists, has implications for better understanding chemotherapy-resistant cancers as well as neurological disorders. The paper, published in Cell Reports, cites Kerafast’s MultiDsk Ubiquitin Binding Protein Reagent, which allows for the capture 

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Promising discovery for T-cell leukemia

In 10% of pediatric T-cell leukemia patients, the BCL-2 protein is overproduced due to a defect in the ribosomes, where proteins for cells are synthesized. A BCL-2 inhibiting drug is currently being used to treat chronic lymphocytic leukemia, but researchers at KU Leuven in Belgium are conducting studies to apply the drug to T-cell leukemia 

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Using stem cells to treat heart failure

The number one cause of death in the world is heart failure, according to the World Health Organization. Causing 80% of the 17.7 million global cardiovascular disease deaths annually, heart failure caused by heart attack or stroke is a huge public health concern. A new study by researchers at the University of Washington has given 

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Rock, Paper, Scissors: P53, the Stock Market, and CRISPR

By Netanya Y. Spencer, MD, PhD On June 11, 2018, Nature Medicine published two papers side-by-side. In one study, Haapaniemi and colleagues studied immortalized human retinal pigment epithelial cells; in the other study, Ihry and colleagues studied human pluripotent stem cells. Both papers presented one major discovery, which plunged a number of stock prices way 

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Fighting the signs of aging may need to start in your gut

The human microbiome is a community of bacteria, viruses, archaea, and eukaryotic microbes that colonize the body and can influence a variety of physiological functions. The microbiota of the gut is exceptionally diverse compared to other sites of the body. Within the gastrointestinal (GI) tract alone, trillions of bacteria representing over a thousand species can 

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Regenerating dental enamel

A new study, published in Nature Communications, outlines a method of growing mineralized structures with the same properties as dental enamel. The materials could be used for repairing enamel, which – unlike other tissues of the body – is not regenerated by the human body once lost. Enamel loss Enamel is the hardest substance in 

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A New Way to Treat Chemotherapy Pain

A new way to treat chronic pain without the use of opioids was found by researchers at the University of California San Diego School of Medicine. The treatment is a spinal injection containing apolipoprotein A-I binding protein (AIBP), which binds to toll-like receptor 4 (TLR4), a receptor on the surface of cells that detects infectious 

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