In a study published by the Journal of Biological Chemistry, scientists at UPenn School of Veterinary Medicine discovered that the enzyme cytochrome P450 2D6 (CYP2D6) plays a role in triggering Parkinson’s disease and represents a new focus for Parkinson’s treatment. Chemically induced Parkinson’s A few decades ago, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was found to induce the onset
Researchers from Washington State University recently discovered a critical step in the body’s inflammatory response that may aid in the development of anti-inflammatory treatments. Their findings, which were published in the journal Nature Communications, cited an integrin beta 3 antibody developed by researchers at the Blood Center of Wisconsin and now available via the Kerafast
The liver is one of the most common sites of metastatic cancer. Now, a study published in the journal Nature is shedding light on how hepatocytes – the primary functional cells of the liver – are part of a chain reaction that makes the organ vulnerable to cancer cells. We were excited to see the
According to the U.S. Centers for Disease Control and Prevention, colon cancer is the third most common cancer and second leading cause of cancer-related death in the country. Now, food science researchers from the University of Massachusetts Amherst have published a new study in Cancer Research that shows how a set of enzymes can potentially
Findings from an international group of researchers might help in the development of drugs against inflammatory and neurodegenerative diseases. Their paper, published in Cell, describes the crystal structure of the human cannabinoid receptor CB2. Exploring the Endocannabinoid System CB1 and CB2, two cannabinoid receptors, belong to the endocannabinoid system. CB1 receptors are commonly found in
Scientists from the La Jolla Institute of Immunology (LJI) have discovered a way to lessen the effects of T cell exhaustion and make CAR T cell therapies more effective, publishing their results in Nature. We were pleased to see our MC-38 cell line, derived from murine colon adenocarcinoma cells, utilized in the research. The MC-38
Research led by scientists at Brown University now shows that an HIV drug may be able to significantly reduce age-related inflammation and other signs of aging in mice. The collaborative findings — which also included work by researchers from New York University, the University of Rochester, Université de Montréal, the University of Virginia School of
Researchers at the University of Georgia have conducted a study to determine how magnetic forces could potentially be used to treat cancerous tissue. They discovered a new non-invasive way of delivering drugs to cancerous tissue utilizing magnets, and the researchers believe that this form of treatment may ultimately be able to reduce the toxic side
Free calcium in the cytosol is critical for regulating cellular processes in response to intracellular and extracellular stimuli. Calcium signaling involves the opening of calcium channels within the plasma membrane or membranes of intracellular organelles, most notably the endoplasmic reticulum (ER). Extracellular stimuli lead to the release of calcium from the ER in response to
A recent study published in Communications Biology may increase the rate of progress of Alzheimer’s research by providing a very large dataset of differences between healthy and Alzheimer’s disease brains. The dataset has been provided online for any researcher to access free of charge. Funded by Alzheimer’s Research UK, the team included scientists from the