Scientists Identify TRAP1 as Key Driver of Prostate Cancer

About 1 in 7 men will be diagnosed with prostate cancer in their lifetimes, according to the American Cancer Society, making it the second-most common form of cancer in American men. Recently, a potentially promising new therapeutic target for the disease was identified by scientists from The Wistar Institute, one of Kerafast’s providing institutions. The 

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New markers to assess Huntington’s disease progression

Huntington’s disease is a debilitating, progressive disease that is eventually fatal. Affecting nerves of the brain, Huntington’s disease (HD) deteriorates an individual’s mental and physical capabilities over time. A recent study published in The Journal of Experimental Medicine by Stanford University researchers identified potential biomarkers to assess disease progression and analyze treatment effectiveness. Huntington’s disease 

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How the microbiota influences Crohn’s disease

Crohn’s disease (CD) is an inflammatory bowel disease that causes chronic inflammation of the gastrointestinal tract, most commonly in the small intestine. It is estimated that more than a half million people in the United States suffer from CD. The most common symptoms of Crohn’s disease include diarrhea, abdominal cramping and weight loss. The complications 

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Intro to Plasmids and Vectors

Here at Kerafast, our portfolio of available plasmids continues to grow; in recent months, for example, we’ve added Wnt pathway plasmids from the University of Rochester, hepatitis B virus expression plasmids from Penn State College of Medicine and human Bcl-xL plasmids from the University of Louisville. We thought we’d take this opportunity to review what 

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A new perspective on reactive oxygen species

Reactive oxygen species (ROS), often referred to as free radicals, have a bad reputation – and for good reason. At high levels, these reactive forms of oxygen, which have unpaired electrons in their outer orbits, can cause significant cellular damage. For example, they destabilize cell membranes, render proteins nonfunctional and mutate DNA, which then can 

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How well do you know chemokines?

Chemokines are signaling proteins secreted by cells, whose main function is to act as a chemoattractant to guide the migration of nearby cells. Part of the cytokine class of molecules, chemokines are important components of the immune system, forming a complex regulatory network that connects the innate and adaptive immune systems. Chemokines bind G protein-coupled 

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