Dark fluorescence quenchers are non-fluorescent dyes that can modulate the fluorescence signal of an appropriate fluorophore donor in a distance-dependent manner. Dark quenchers are often used in dual-label probes, which combine a reporter dye with a quencher moiety. Typically, these probes may exist in two conformations differing in their fluorescence properties: a ‘closed’ form in
When I first glanced at Kerafast’s mission to increase accessibility of unique reagents and the number of reagents it houses in its catalog, I was immediately drawn to the company. My name is Omnia Eldoghry, and I am a rising junior at Tufts University where I am pursuing a double major in biology and community
Have you created or contributed to the development of a new research reagent? At Kerafast, our mission is to advance scientific research by facilitating access to unique reagents developed in academic laboratories around the world. This quarter, we invite you to share your experience in developing a new research reagent to be featured in our
A recent study conducted by Yale Cancer Center reports the discovery of a new role for STimulator of INterferon Genes (STING) for head and neck cancer treatment. Previously, STING has been related to the immune response involved in DNA damage. However, this study aims to focus on STING’s new role in tumor DNA damage response
Researchers at the University of Plymouth collaborated with the University of College London and the Universities of Cambridge and Southampton to demonstrate that cells can adapt to conditions in critically ill patients by producing energy more efficiently than in healthy patients. Their research was published in Redox Biology. Oxygen and the Electron Transport Chain Within
A study published in Nature highlights how chemicals in the tumor microenvironment can manipulate the immune system to prevent the immune response that attacks cancer. The research, conducted by a team of scientists at the University of Pittsburgh School of Medicine and UPMC Hillman Cancer Center, suggests an already existing drug could be applied to
The Pirbright Institute recently developed the first-ever pig antibodies against influenza. The study published in PLOS Pathogens proves successful protection against flu infections, validating that the new antibodies can be used for model studies of human antibody therapeutics and vaccines. The Pirbright team collaborated with the University of Oxford, The Francis Crick Institute and The
A research team led by Igor Stagljar at University of Toronto has been working to develop a new method of measuring the level of immunity to coronavirus in individuals who have recovered from COVID-19. Through their research, they have created a pinprick test that quickly and accurately measures the concentration of coronavirus antibodies in blood.
I am a 3rd year PhD student conducting my research in Dr. Sathyanarayanan Puthanveettil’s lab at Scripps Research, Florida. My research goal is to understand the significance and regulation of bidirectionally transported organelles within the axon during learning and memory. Specifically, I study the transport of mitochondria (that supplies energy) and lysosomes (that degrades and
The female mosquito, Aedes aegypti, is a day-biting mosquito, taking a single or multiple blood meals, to obtain the necessary vitamins and nutrients for her egg development1. However, upon ingesting a large blood meal, adult females face the challenge of haemolymph (blood) ion dilution, as they take on a significant water load. To cope with