Hydrodabcyl: a superior hydrophilic alternative to the dark fluorescence quencher dabcyl

Dark fluorescence quenchers are non-fluorescent dyes that can modulate the fluorescence signal of an appropriate fluorophore donor in a distance-dependent manner. Dark quenchers are often used in dual-label probes, which combine a reporter dye with a quencher moiety. Typically, these probes may exist in two conformations differing in their fluorescence properties: a ‘closed’ form in 

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