Kerafast

Studying insulin signaling using trans-omic analysis

University of Tokyo researchers have shown different insulin concentrations activate different cell signaling pathways, findings that may lead to better treatments for diabetes. The researchers tracked the effects of insulin using a trans-omics approach, combining multiple databases and large-scale experiments, and published their results in the journal iScience. We were excited to see our puromycin 

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New heart disease genetic risk factor discovered

Atherosclerotic disease – the narrowing of arteries due to plaque buildup – is a leading cause of death worldwide. It causes 15 million lives to be lost each year around the world, with 610,000 deaths estimated in the United States alone. In a new study, researchers have pinpointed one more reason why some people are 

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Using a gut-on-a-chip model to study intestinal inflammation

Intestinal inflammation involves a complex interaction between intestinal epithelial cells, intestinal microbiota and immune cells. Many factors are known to be involved in the onset of intestinal inflammation; however, an inciting factor responsible for triggering inflammation has not been identified. The ability to identify an inciting factor has been hampered by the lack of animal-based 

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Freeze-dried polio vaccine could end the disease

University of Southern California researchers have developed an injectable freeze-dried polio vaccine that can be kept at room temperature in powder form for four weeks and then rehydrated without losing efficacy in mice. Because the vaccine doesn’t need refrigeration, it could potentially be used throughout more remote parts of the world where polio still lurks, 

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We’ve moved! Take a tour of our new office

The Kerafast team has now officially moved into our new office space! We’re still in the same building, located on the water in Boston’s Innovation District. We’re even on the same floor, so our address remains the same. However, we’ve excited to have upgraded to a larger space, complete with a bigger lab and shipping 

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Fighting infection with antibacterial drones

The prevalence of antibiotic-resistant bacteria is an ever-growing problem that poses a significant threat to global health. An increasing number of infectious diseases are becoming more difficult, and in some cases impossible, to treat. While new antibiotics are being developed, it is unlikely that they will be effective against the most dangerous antibiotic-resistant bacteria. To 

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Mapping the brain for targeted therapies

While the brain has been significantly studied and its various regions identified, a new study by researchers at the University of Southern California published in the journal Nature Neuroscience describes a detailed map of the hippocampus that holds promise for new treatments. The hippocampus The hippocampus is located at the base of the brain and 

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Potential cancer treatment found in alpaca’s immune system

An Institute for Research in Biomedicine (IRB Barcelona) and Vrije Universiteit Brussel (VUB) study describes camelid nanobodies with the capacity to block the activity of EGF (Epidermal Growth Factor), a protein that is abnormally regulated in cancer cells. Nanobody overview Nanobodies are an exciting area of research with the potential to help in the generation 

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Protection against Legionnaires’ disease and other lung infections

An international team of researchers has shown that MAIT cells, recently discovered immune cells whose exact function remains unclear, play a role in protecting against two strains of Legionella bacteria, which cause the lung infection Legionnaire’s disease. The results, published in Nature Communications, offer a potential new approach for protecting people against lung infections. We 

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