Researchers have visualized macrophages transferring cytoplasm to melanoma tumor cells, contact which in turn alters tumor cell migration and stimulates cancer metastasis. The study, which cites our MC-38 adenocarcinoma cell line, was recently published in the journal Developmental Cell. Macrophages: good or bad guys? Macrophages are white blood cells that digest pathogens and cellular debris.
The development of antibiotic resistance in bacteria is a global health issue that limits the prevention and treatment of infections. Patients infected with antibiotic-resistant bacteria have worse clinical outcomes with a higher risk of death and consume more healthcare resources than patients infected with non-resistant strains of the same bacteria. Given the significant clinical and
Human immunodeficiency virus (HIV) came into the colloquial vocabulary in the 1980s when a growing number of homosexual men and intravenous drug users presented with unusual symptoms synonymous with an impaired immune system. These groups demonstrated clinical signs of a rare opportunistic infection, Pneumocystis crinii pneumonia, that had previously only been seen in patients who
In humans, we utilize an essential nutrient, choline, converting it to phosphocholine and phosphatidylcholine. Phosphatidylcholines (PCs) are important components of biological membranes of both plants and animals. Mechanisms differ in terms of how the PCs are generated. The Kennedy pathway is used in mammals, fungi and some bacteria, while in yeast as well as mammals